COPD VIDEO LIBRARY

Explore relevant video clips where experts discuss different aspects of COPD. These short videos cover a wide range of COPD topics, such as assessment and symptoms. These discussions are clinical in nature and are for disease state education; they are not meant to imply efficacy or safety of any products. Check back often for new video postings and to watch clips anytime.

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USING SPIROMETRY TO DIAGNOSE COPD

Gary T. Ferguson, MD

Pulmonary Research Institute of Southeast Michigan

Providence Medical Center

Michigan State University

Farmington Hills, Michigan

Ron Balkissoon, MD

National Jewish Health-Denver

University of Colorado Hospital

Denver, Colorado

Gary T. Ferguson, MD

Pulmonary Research Institute of Southeast Michigan

Providence Medical Center

Michigan State University

Farmington Hills, Michigan

Richard Casaburi, PhD, MD

Professor of Medicine

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

Torrance, California

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COPD: IN-DEPTH PERSPECTIVES

Watch an in-depth, expert perspective on diagnosis and assessment of symptoms in COPD.

COPD: ASSESSMENT AND CONSIDERATIONS

GOLD REPORT UPDATE: BRIEF SUMMARY

In 2017, the GOLD Report released a major update of the latest research data and expert opinion, which remains consistent today. Prior to 2017, the last major update was in 2011. These discussions highlight some of the revised components.

 

IMPORTANT SAFETY INFORMATION, INCLUDING BOXED WARNING

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IMPORTANT SAFETY INFORMATION, INCLUDING BOXED WARNING

WARNING: Long-acting beta2-adrenergic agonists (LABAs), such as formoterol fumarate, one of the active ingredients in BEVESPI AEROSPHERE, increase the risk of asthma-related death. A placebo-controlled trial with another LABA (salmeterol) showed an increase in asthma-related deaths in subjects receiving salmeterol. This finding with salmeterol is considered a class effect of all LABAs, including formoterol fumarate.

The safety and efficacy of BEVESPI AEROSPHERE in patients with asthma have not been established. BEVESPI AEROSPHERE is not indicated for the treatment of asthma.

CONTRAINDICATIONS

All LABAs are contraindicated in patients with asthma without use of a long-term asthma control medication. BEVESPI is contraindicated in patients with hypersensitivity to glycopyrrolate, formoterol fumarate, or to any component of the product.

WARNINGS AND PRECAUTIONS

  • BEVESPI should not be initiated in patients with acutely deteriorating chronic obstructive pulmonary disease (COPD), which may be a life-threatening condition

  • BEVESPI should not be used for the relief of acute symptoms (ie, as rescue therapy for the treatment of acute episodes of bronchospasm). Acute symptoms should be treated with an inhaled short-acting beta2-agonist

  • BEVESPI should not be used more often or at higher doses than recommended, or with other LABAs, as an overdose may result

  • If paradoxical bronchospasm occurs, discontinue BEVESPI immediately and institute alternative therapy

  • If immediate hypersensitivity reactions occur, in particular, angioedema, urticaria, or skin rash, discontinue BEVESPI at once and consider alternative treatment

  • BEVESPI can produce a clinically significant cardiovascular effect in some patients, as measured by increases in pulse rate, blood pressure, or symptoms. If such effects occur, BEVESPI may need to be discontinued

  • Use with caution in patients with convulsive disorders, thyrotoxicosis, diabetes mellitus, ketoacidosis, and in patients who are unusually responsive to sympathomimetic amines

  • Be alert to hypokalemia and hyperglycemia

  • Worsening of narrow-angle glaucoma or urinary retention may occur. Use with caution in patients with narrow-angle glaucoma, prostatic hyperplasia, or bladder-neck obstruction, and instruct patients to contact a physician immediately if symptoms occur

ADVERSE REACTIONS

The most common adverse reactions with BEVESPI (≥2% and more common than placebo) were: cough, 4.0% (2.7%), and urinary tract infection, 2.6% (2.3%).

DRUG INTERACTIONS

  • Use caution if administering additional adrenergic drugs because the sympathetic effects of formoterol may be potentiated

  • Concomitant treatment with xanthine derivatives, steroids, or diuretics may potentiate any hypokalemic effect of formoterol

  • Use with caution in patients taking non–potassium-sparing diuretics, as the ECG changes and/or hypokalemia may worsen with concomitant beta2-agonists

  • The action of adrenergic agonists on the cardiovascular system may be potentiated by monoamine oxidase inhibitors, tricyclic antidepressants, or other drugs known to prolong the QTc interval. Therefore, BEVESPI should be used with extreme caution in patients being treated with these agents

  • Use beta-blockers with caution as they not only block the therapeutic effects of beta-agonists, but may produce severe bronchospasm in patients with COPD

  • Avoid co-administration of BEVESPI with other anticholinergic-containing drugs as this may lead to an increase in anticholinergic adverse effects

INDICATION

BEVESPI AEROSPHERE is a combination of glycopyrrolate, an anticholinergic, and formoterol fumarate, a long-acting beta2-adrenergic agonist (LABA), indicated for the long-term, maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and/or emphysema.

LIMITATION OF USE

Not indicated for the relief of acute bronchospasm or for the treatment of asthma.

Please read full Prescribing Information, including Boxed WARNING, and Medication Guide and Instructions for Use for BEVESPI AEROSPHERE.

You may report side effects related to AstraZeneca products by clicking here.